Medication Related Osteonecrosis of the Jaw (MRONJ). Review and recent advances

Abstract Medication-Related Osteonecrosis of the Jaw (MRONJ) is defined as a complication, which affects jawbone patients that meet all following criteria: (a) were in past or are now on treatment with bone targeting agents (BTAs) and/or antiangiogenics, (b) they have exposed can be probed through an intraoral extraoral fistula for more than 8 weeks, and (c) no history radiotherapy obvious metastatic disease to jaws. Since first reports, 2003, plethora articles MRONJ significantly increased our knowledge this potentially serious complication. However, controversies about definition clinical presentation, risk factors, radiological findings, staging early diagnosis, prevention may affect successful management quality life cancer patients. The purpose article present current recent advances best practice treatment. Important questions will discussed, including following: (1) Should we wait weeks when patient antiresorptive therapy, presents necrotic jawbone? (2) Can exclude diagnosis osteonecrosis if without bone? (3) Is dental extraction factor MRONJ? (4) perform extraction, antiresorptives, symptomatic tooth? (5) What role periodontal infection? (6) Shall re-start antiresorptives healing previous